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Bursar
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General Practitioner,
Department of Economics and Management,
Department of Mathematics
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Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461373 / VAT: CZ60461373
Czech Post certified digital mail code: sp4j9ch
Copyright: UCT Prague
Information provided by the Department of International Relations and the Department of R&D. Technical support by the Computing Centre.
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- Video z Festivalu vědy 2021
- Čeští vědci se podíleli na objevu nového řízení mikrorobotů (Lidovky)
- Mikroroboti z gelu a zlata řízení světlem? Žádné sci-fi, ale realita v podání českých vědců (Česká televize)
https://www.svetchytre.cz/a/pUZaW/cesti-vedci-vyvinuli-mikroskopicke-roboty-ze-zlata-pomuzou-napriklad-v-biomedicine
https://www.technickytydenik.cz/rubriky/denni-zpravodajstvi/mikroroboti-z-gelu-a-zlata-rizeni-svetlem_50495.html
https://sciencemag.cz/mikroroboti-z-gelu-a-zlata-rizeni-svetlem/
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https://www.tyden.cz/rubriky/veda/objev-ceskych-vedcu-pomuze-odhalit-padelana-leciva_544272.html
https://www.cysnews.cz/ostatni/novy-objev-odhali-padelana-leciva-a-posune-vyvoj-umelych-tkani/
https://media.monitora.cz/pdf-preview/1976/84369542-80531973c3e60af049de/
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Currently one funded PhD. position available!
This project combines chemical and lithographic approaches to create interactive autonomous hydrogel microcrawlers that locomote through periodic actuation when exposed to an appropriate stimulus (light, magnetic field). The crawlers’ trajectories are controlled by external field gradients in a similar manner to photo, chemo and magnetotaxis in unicellular organisms, which allows controlling simultaneously position of multiple crawlers in both space and time. Such crawlers can be used to autonomously manipulate microobjects, deliver chemical cargo to the place of interest or probe and report on the composition of their surroundings. Reversible assembly of the crawlers into ordered macroscopic actuating structures is the next goal of the project.
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[ikona] => skupina [obrazek] => [ogobrazek] => [pozadi] => [obsah] => |
Ivan RehorGroup leader |
 |
Yadu Nath Vakkipurath KodakkadanPh.D. student |
 |
Charlie MaslenPh.D. student |
Damla OrhanPh.D. student |
|
Jindrich KropacekMaster student |
|
Renata SvecovaBachelor student |
|
Eliska PazderkovaBachelor student |
|
Jan DurasBachelor student |
|
Radek HomolaBachelor student |
Kodakkadan, Y. N. V.; Idzakovicova, K.; Sepitka, J.; Napel, D. ten; Safai, E.; Cigler, P.; Štěpánek, F.; Rehor, I. Arbitrarily-Shaped Microgels Composed of Chemically Unmodified Biopolymers. Biomater. Sci. 2020. https://doi.org/10.1039/C9BM02056J.
Rehor, I.; Maslen, C.; Moerman, P. G.; van Ravensteijn, B. G. P.; van Alst, R.; Groenewold, J.; Eral, H. B.; Kegel, W. K. Photoresponsive Hydrogel Microcrawlers Exploit Friction Hysteresis to Crawl by Reciprocal Actuation. Soft Robot. 2020. https://doi.org/10.1089/soro.2019.0169
|
|
 Rehor, I.; van Vreeswijk, S.; Vermonden, T.; Hennink, W. E.; Kegel, W. K.; Eral, H. B. Biodegradable Microparticles for Simultaneous Detection of Counterfeit and Deteriorated Edible Products. Small 2017, 13 (39), 1701804. https://doi.org/ 10.1002/smll.201701804. |
 Slegerova, J.; Hajek, M.; Rehor, I.; Sedlak, F.; Stursa, J.; Hruby, M.; Cigler, P. Designing the Nanobiointerface of Fluorescent Nanodiamonds: Highly Selective Targeting of Glioma Cancer Cells. Nanoscale 2015, 7 (2), 415–420. https://doi.org/ 10.1039/C4NR02776K. |
| Rehor, I.; Lee, K. L.; Chen, K.; Hajek, M.; Havlik, J.; Lokajova, J.; Masat, M.; Slegerova, J.; Shukla, S.; Heidari, H.; et al. Plasmonic Nanodiamonds: Targeted Core–Shell Type Nanoparticles for Cancer Cell Thermoablation. Adv. Healthcare Mater. 2015, 4 (3), 460–468. https://doi.org/ 10.1002/adhm.201400421. |
| Petrakova, V.; Rehor, I.; Stursa, J.; Ledvina, M.; Nesladek, M.; Cigler, P. Charge-Sensitive Fluorescent Nanosensors Created from Nanodiamond. Nanoscale 2015. https://doi.org/ 10.1039/C5NR00712G. |
 Rehor, I.; Slegerova, J.; Kucka, J.; Proks, V.; Petrakova, V.; Adam, M.-P.; Treussart, F.; Turner, S.; Bals, S.; Sacha, P.; et al. Fluorescent Nanodiamonds Embedded in Biocompatible Translucent Shells. Small 2014, 10 (6), 1106–1115. https://doi.org/ 10.1002/smll.201302336. |
 Rehor, I.; Mackova, H.; Filippov, S. K.; Kucka, J.; Proks, V.; Slegerova, J.; Turner, S.; Van Tendeloo, G.; Ledvina, M.; Hruby, M.; et al. Fluorescent Nanodiamonds with Bioorthogonally Reactive Protein-Resistant Polymeric Coatings. ChemPlusChem 2014, 79 (1), 21–24. https://doi.org/ 10.1002/cplu.201300339. |
|
Řehoř, I.; Macháčková, L.; Bučánková, A.; Matějková, S.; Černá, K.; Straka, J. Measuring the Sugar Consumption of Larvae in Bumblebee Micro-Colonies: A Promising New Method for Tracking Food Economics in Bees. Apidologie 2014, 45 (1), 116–128. https://doi.org/ 10.1007/s13592-013-0233-6. |
|
Rehor, I.; Cigler, P. Precise Estimation of HPHT Nanodiamond Size Distribution Based on Transmission Electron Microscopy Image Analysis. Diamond and Related Materials 2014, 46, 21–24. https://doi.org/ 10.1016/j.diamond.2014.04.002. |
|
Chu, Z.; Zhang, S.; Zhang, B.; Zhang, C.; Fang, C.-Y.; Rehor, I.; Cigler, P.; Chang, H.-C.; Lin, G.; Liu, R.; et al. Unambiguous Observation of Shape Effects on Cellular Fate of Nanoparticles. Scientific Reports 2014, 4, 4495. https://doi.org/ 10.1038/srep04495. |
|
|
| Berkova, Z.; Jirak, D.; Zacharovova, K.; Lukes, I.; Kotkova, Z.; Kotek, J.; Kacenka, M.; Kaman, O.; Rehor, I.; Hajek, M.; et al. Gadolinium- and Manganite-Based Contrast Agents with Fluorescent Probes for Both Magnetic Resonance and Fluorescence Imaging of Pancreatic Islets: A Comparative Study. ChemMedChem 2013, 8 (4), 614–621. https://doi.org/ 10.1002/cmdc.201200439. |
| Řehoř, I.; Vilímová, V.; Jendelová, P.; Kubíček, V.; Jirák, D.; Herynek, V.; Kapcalová, M.; Kotek, J.; Černý, J.; Hermann, P.; et al. Phosphonate–Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic–Therapeutic Nanoprobes. J. Med. Chem. 2011, 54 (14), 5185–5194. https://doi.org/ 10.1021/jm200449y. |
|
Řehoř, I.; Kubíček, V.; Kotek, J.; Hermann, P.; Száková, J.; Lukeš, I. Modification of Nanocrystalline TiO2 with Phosphonate- and Bis(Phosphonate)-Bearing Macrocyclic Complexes: Sorption and Stability Studies. Eur. J. Inorg. Chem. 2011, 2011 (12), 1981–1989. https://doi.org/ 10.1002/ejic.201001100. |
| Řehoř, I.; Kubíček, V.; Kotek, J.; Hermann, P.; Lukeš, I.; Száková, J.; Vander Elst, L.; Muller, R. N.; Peters, J. A. 1H NMR Relaxivity of Aqueous Suspensions of Titanium Dioxide Nanoparticles Coated with a Gadolinium(III) Chelate of a DOTA-Monoamide with a Phenylphosphonate Pendant Arm. J. Mater. Chem. 2009, 19 (10), 1494–1500. https://doi.org/ 10.1039/b817065g. |
| Kubíček, V.; Řehoř, I.; Havlíčková, J.; Kotek, J.; Císařová, I.; Hermann, P.; Lukeš, I. Synthesis and Coordination Behavior of Symmetrical Tetraamine Phosphinic Acids. Eur. J. Inorg. Chem. 2007, 2007 (24), 3881–3891. https://doi.org/ 10.1002/ejic.200700010. |
Vavra, J.; Rehor, I.; Rendler, T.; Jani, M.; Bednar, J.; Baksh, M. M.; Zappe, A.; Wrachtrup, J.; Cigler, P. Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications. Advanced Functional Materials 2018, 28 (45), 1803406. https://doi.org/ 
Havlik, J.; Petrakova, V.; Rehor, I.; Petrak, V.; Gulka, M.; Stursa, J.; Kucka, J.; Ralis, J.; Rendler, T.; Lee, S.-Y.; et al. Boosting Nanodiamond Fluorescence: Towards Development of Brighter Probes. Nanoscale 2013, 5 (8), 3208–3211. https://doi.org/ Book chapters:
Řehoř, I.; Šlegerová, J.; Havlík, J.; Raabová, H.; Hývl, J.; Muchová, E.; Cígler, P. Nanodiamonds: Behavior in Biological Systems and Emerging Bioapplications. In Carbon Nanomaterials for Biomedical Applications; Zhang, M., Naik, R. R., Dai, L., Eds.; Springer Series in Biomaterials Science and Engineering; Springer International Publishing, 2016; pp 319–361. https://doi.org/ 10.1007/978-3-319-22861-7_11.
Slegerova, J.; Rehor, I.; Havlik, J.; Raabova, H.; Muchova, E.; Cigler, P. Nanodiamonds as Intracellular Probes for Imaging in Biology and Medicine. In Intracellular Delivery II; Prokop, A., Iwasaki, Y., Harada, A., Eds.; Fundamental Biomedical Technologies; Springer Netherlands, 2014; pp 363–401.
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In our group, we combine chemical and lithographic approaches to create interactive programable hydrogel microparticles (microgels) which serve as microscopic soft robots, building blocks for artificial tissues, in-vivo sensors, and others. To achieve that, we aim to develop following key abilities of the microgels:
Responsiveness
The microgel detects changes in its environment and respond to them
Mobility
The microgel reaches the desired location in (biological) environment, either passively by tailored set of properties, or actively through microgel locomotion, resembling motion of unicellular organisms.
Connectivity
Individual microgels can assemble autonomously into ordered structures.
Temporal programming
The microgel properties are subject to pre-programmed spontaneous changes.
Biocompatibility
The microgels consist from materials tolerated in-vivo to avoid adverse interactions with their living surrounding.
Our research projects include:
Artificial Cells
Lithographic Bio-microgels
Authenticity labels for pharmaceuticals
Hydrogel Robots
Self-assembly
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Responsiveness
The microgel detects changes in its environment and respond to them
Mobility
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Connectivity
Individual microgels can assemble autonomously into ordered structures.
Temporal programming
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Biocompatibility
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Our research projects include:
Artificial Cells
Lithographic Bio-microgels
Authenticity labels for pharmaceuticals
Hydrogel Robots
Self-assembly
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[obsah] => Red blood cell has a discoidal shape around 10 μm in diameter and circulates effortlessly through the bloodstream, although the capillaries are as thin as 5 μm. This unique ability is given by their shape, mechanical properties (elasticity, shear thinning) and surface. In this project, we aim to synthesize degradable hydrogel microparticles that mimic these red blood cells properties and thus have in their ability to circulate in the bloodstream for a prolonged period of time (days). These microgels will be used for remote sensing of blood composition.
Figure: Lithographic hydrogel microparticle mimicks the size and shape of the red blood cell
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[obsah] => Microgels proved to be an essential tool in many biomedical applications, including drug release, tissue engineering or cell therapy applications. The control over microgel size, shape, chemical composition and mechanical properties is required in these applications. Lithographic synthesis of the microgels is the only known way to achieve this control. These, however, require synthetic photocrosslinkable polymers, which can induce biocompatibility issues upon their in-vivo application. The use of natural biopolymers in bioapplications would represent a superior alternative, but natural biopolymers cannot be shaped using photolithographic techniques.
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Figure: Sechematic process of microgel fabrication
Figure: Arbitrarily-shaped alginate microgels
Kodakkadan, Y. N. V.; Idzakovicova, K.; Sepitka, J.; Napel, D. ten; Safai, E.; Cigler, P.; Štěpánek, F.; Rehor, I. Arbitrarily-Shaped Microgels Composed of Chemically Unmodified Biopolymers. Biomater. Sci. 2020. https://doi.org/10.1039/C9BM02056J
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[nazev] => Authenticity microlabels
[seo_title] => Authenticity microlabels for pharmaceuticals
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[obsah] => Counterfeit consumer goods are on the rise globally. The situation is extraordinarily alarming in the case of pharmaceutical products, 10% of all pharmaceuticals sold world-wide are counterfeits or of substandard quality, reaching 30% in developing countries. We developed multifunctional biodegradable hydrogel microparticles as taggants for food and pharmaceutical products. The microparticles provide simultaneous information on the product authenticity and safety directly prior to consumption. The authenticity information is embedded in the microparticle topography as a binary code. The product safety of liquid products—the presence of the pathogens and the potential product deterioration due to improper storage—is reported through the sensors embedded in the microparticle structure. The authenticity code and the sensor information are acquired with a standard bright-field/fluorescent microscope or even low-cost microscopic smartphone addon.
Figure: Microbarcodes, composed from biodegradable hydrogel, placed on various pharmaceutical products
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[nazev] => Hydrogel Robots
[seo_title] => Hydrogel Robots
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[obsah] => Miniaturization of robots can radically change multiple areas of human activity, such as healthcare, where microrobots were proposed for various applications including cell/drug delivery or microsurgery. Pivotal to the development of such robots is exploring of untethered locomotion mechanisms that are efficient on the microscale. In our projects we are developing hydrogel microrobots lovcomoting through swimming or crawling, harvesting electromagnetic radiation from their surrounding for their propulson. The robots are taylored for specific tasks, for example as micromanipulators.
Figure: Hydrogel Microcrawler driven by focused laser
Rehor, I.; Maslen, C.; Moerman, P. G.; van Ravensteijn, B. G. P.; van Alst, R.; Groenewold, J.; Eral, H. B.; Kegel, W. K. Photoresponsive Hydrogel Microcrawlers Exploit Friction Hysteresis to Crawl by Reciprocal Actuation. Soft Robot. 2020. https://doi.org/10.1089/soro.2019.0169.
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[nazev] => Self-Assembly
[seo_title] => Self-Assembly
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[obsah] => Complex structures in nature are often composed of elemental subunits, which are not mounted together by an intelligent designer, instead they spontaneously self-assemble based on protocols 'coded' in each subunit. Taking inspiration form the nature and use self-assembly in man-made systems is a tempting alternative to current manufacture routines, relying mainly on direct ‘pick and place’ techniques. Numerous functional self-assembling systems were reported at supramolecular and even colloidal scale. At larger lengthscales, however, utilization of self-assembly as a construction approach is scarce, mainly due to the absence of thermal motion of micro/macroscaled building blocks. We aim to exploit the methods of microscale self-assembly for construction of ordered structures and subsequently use these as self-assembled artificial tissues and as self-assembled robots.
Figure: Microgel discs 100 micron in diameter, assembled into ordered hexagonal sheet.
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